Health Effects Assessment for Environmental Perchlorate Contamination
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چکیده
1386. Toxicol Sci 60:291–292 (2001). 26. Narayanan L, Yu KY, Mattie DR, Fisher JW. Perchlorate induced thyroid hormonal changes in pregnant and lactating female rats, fetuses and nursing pups. Abstract 2069. Toxicol Sci 60:434 (2001). 27. Fisher J, Todd P, Mattie D, Godfrey D, Narayanan L, Yu K. Preliminary development of a physiological model for perchlorate in the adult male rat: a framework for further studies. Drug Chem Toxicol 23:243–258 (2000). 28. Fisher JW, Jarabek A, Mattie D, Merrill E. Species comparison of inhibition of radioiodide uptake in the thyroid by perchlorate using physiological models. Abstract 707. Toxicol Sci 60:148 (2001). 29. Merrill EA, Clewell RA, Gearhart JM. Comparison of Internal Dosimetrics Using PBPK Models for Perchlorate Induced Inhibition of Thyroid Iodide Uptake and Sensitivity Analysis for Male Rat Model. Consultative Letter: AFRLHE-WP-CL-2001-0010. Wright-Patterson AFB:U.S. Air Force Research Laboratory, 2001. 30. Merrill EA, Clewell RA, Gearhart JM, Robinson PJ, Sterner TR, Narayanan L, Yu KO, Fisher JW. PBPK Model for Iodide Kinetics and Perchlorate-Induced Inhibition in the Male Rat. Consultative Letter: AFRL-HE-WP-CL-2001-0005. Wright-Patterson AFB:U.S. Air Force Research Laboratory,
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Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans.
Application of a sensitive new detection method has revealed widespread perchlorate contamination of groundwater in the southwestern United States, typically at 0.005-0.020 mg/L (5-20 ppb). Perchlorate is a competitive inhibitor of the process by which iodide is actively transported from the bloodstream into the thyroid. This inhibitory action of perchlorate is the basis of its pharmaceutical u...
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